How Aliskiren-Amlodipine-Hydrochlorothiazide Works
Drug InteractionsAliskiren-amlodipine-hydrochlorothiazide may react with a number of other medications (see Drug Interactions With Aliskiren-Amlodipine-Hydrochlorothiazide).
What If I Overdose on This Medicine?An overdose on this drug is likely to cause dangerously low blood pressure (hypotension), a rapid heart rate (tachycardia), electrolyte imbalances, and other serious problems. If you happen to overdose on aliskiren-amlodipine-hydrochlorothiazide, seek immediate medical attention.
(Click Amturnide Overdose for more information.)
What If I Miss a Dose of Aliskiren-Amlodipine-Hydrochlorothiazide?If you forget to take your dose, take it as soon as you remember, unless it is almost time for the next dose. In this case, simply skip the missed dose and continue with your regular schedule. Do not take a double dose.
How Does It Work?As the name implies, aliskiren-amlodipine-hydrochlorothiazide contains three different medications. Amlodipine is a calcium channel blocker. It helps slow down the rate at which calcium moves into the blood vessel walls. This, in turn, helps to relax the vessels, which improves blood flow and lowers blood pressure.
Aliskiren belongs to a class of drugs called renin inhibitors. Renin is an enzyme produced in the kidneys that acts throughout the body. It converts angiotensinogen to angiotensin I. A different enzyme (angiotensin-converting enzyme, or ACE) then converts angiotensin I to angiotensin II, a powerful substance that increases blood pressure by narrowing blood vessels and indirectly stimulating the kidneys to retain salt.
Hydrochlorothiazide is a diuretic, which is commonly referred to as a "water pill." It works by increasing the amount of salt and water the kidneys remove from the blood. This extra salt and water then is passed out through the urine. By increasing the amount of water removed from the blood, hydrochlorothiazide decreases blood volume. Because of this effect, hydrochlorothiazide can lower blood pressure and also help with water retention.