Effects of Aliskiren-Amlodipine-Hydrochlorothiazide Interactions
More Detail on Drug Interactions With Aliskiren-Amlodipine-HydrochlorothiazideThe following sections explain in detail the potentially negative interactions that can occur when aliskiren-amlodipine-hydrochlorothiazide is combined with any of the drugs listed above.
Combining aliskiren-amlodipine-hydrochlorothiazide with ACE inhibitors can increase your risk for high potassium levels in your blood (hyperkalemia). Your healthcare provider should check your potassium levels regularly. The hydrochlorothiazide in aliskiren-amlodipine-hydrochlorothiazide can counteract this effect, since hydrochlorothiazide can cause low potassium levels, so this interaction may be somewhat unpredictable.
Combining these medications may also increase the risk of dangerously low blood pressure (hypotension) and kidney failure. Aliskiren-amlodipine-hydrochlorothiazide should never be combined with an ACE inhibitor in people with diabetes, because they may have a higher risk for these complications. Also, such combinations are not recommended for people with moderate-to-severe kidney problems.
Drinking alcohol while taking aliskiren-amlodipine-hydrochlorothiazide can increase your risk for low blood pressure, especially when sitting or standing up suddenly. Talk to your healthcare provider about drinking alcohol when taking this drug.
Amiloride or Amiloride-HCTZ
Aliskiren-amlodipine-hydrochlorothiazide may interact with amiloride. Taking these two drugs together increases your risk for high potassium levels (hyperkalemia). However, the hydrochlorothiazide in this medicine can counteract this effect, since hydrochlorothiazide can cause low potassium levels, so this interaction may be somewhat unpredictable.