Interactions Between Itraconazole and Aliskiren-Amlodipine-Hydrochlorothiazide
Itraconazole can significantly increase the level of aliskiren (one of the active ingredients in aliskiren-amlodipine-hydrochlorothiazide) in your blood. These medications should not be taken together.
Taking hydrochlorothiazide (one of the active ingredients in aliskiren-amlodipine-hydrochlorothiazide) with lithium may increase the level of lithium in your blood, increasing your chance of side effects. In general, lithium is usually not recommended to be taken with diuretics, including hydrochlorothiazide. Your healthcare provider may need to monitor your lithium level more closely and adjust your dose as necessary.
Nonsteroidal Anti-inflammatory Drugs (NSAIDs)
Aliskiren-amlodipine-hydrochlorothiazide can interact with NSAIDs in several ways. The combination could cause your blood pressure to increase or may cause swelling (edema), especially if you have congestive heart failure (CHF). If you are elderly, have kidney disease or kidney failure, or are taking a diuretic ("water pill") or are dehydrated, taking NSAIDs and aliskiren-amlodipine-hydrochlorothiazide together may cause kidney failure. Talk to your healthcare provider about this potential drug interaction before taking these products together.
While taking aliskiren-amlodipine-hydrochlorothiazide, do not take any potassium products unless your healthcare provider specifically tells you to do so. The hydrochlorothiazide in aliskiren-amlodipine-hydrochlorothiazide can cause low potassium levels, so this interaction may be somewhat unpredictable. Some people taking aliskiren-amlodipine-hydrochlorothiazide might develop low potassium due to the hydrochlorothiazide and may need potassium supplementation.
Combining aliskiren-amlodipine-hydrochlorothiazide with medications that contain triamterene can increase your risk for high potassium levels in your blood (hyperkalemia). Your healthcare provider should check your potassium levels regularly. However, the hydrochlorothiazide in aliskiren-amlodipine-hydrochlorothiazide can counteract this effect, since hydrochlorothiazide can cause low potassium levels, so this interaction may be somewhat unpredictable.