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Are There Risks With Aliskiren-Amlodipine-Hydrochlorothiazide?

Specific Aliskiren-Amlodipine-Hydrochlorothiazide Precautions and Warnings

Some warnings and precautions to be aware of prior to taking this medication include the following:
  • If you have liver disease, your body may not metabolize aliskiren-amlodipine-hydrochlorothiazide as well as it should. Therefore, you may require extra monitoring by your healthcare provider and you may need to take a lower dosage.
  • This medication may cause a decrease in kidney function, especially in people who are elderly, have kidney disease, have severe congestive heart failure (CHF), or are taking nonsteroidal anti-inflammatory drugs (NSAIDs) or diuretics (water pills). Your healthcare provider may choose to monitor your kidney function with a blood test while you are taking aliskiren-amlodipine-hydrochlorothiazide. Contact your healthcare provider if you notice a decrease in urination or swelling in your hands, legs, ankles, or feet, which can be signs of kidney problems.
  • If you have severe coronary artery disease, there is a low possibility that taking aliskiren-amlodipine-hydrochlorothiazide could make chest pain worse or lead to a heart attack.
  • This medicine has not been studied in people with heart failure. Medications like aliskiren-amlodipine-hydrochlorothiazide should be used with caution and extra monitoring in people with heart failure.
  • People with asthma have an increased risk for allergic reactions to hydrochlorothiazide, one of the active ingredients in aliskiren-amlodipine-hydrochlorothiazide.



  • Drugs that contain hydrochlorothiazide, including aliskiren-amlodipine-hydrochlorothiazide, can sometimes cause a potentially dangerous type of glaucoma. This reaction usually occurs within days to weeks of starting the drug. Because this reaction can permanently damage vision, let your healthcare provider know right away if you develop vision changes and/or eye pain. The main treatment for this reaction is to stop taking this medication, although other treatment or surgery may sometimes be necessary.
  • Aliskiren-amlodipine-hydrochlorothiazide may affect electrolytes in the blood, including sodium, calcium, potassium, magnesium, and chloride. Therefore, your healthcare provider will regularly check these levels. If you notice any symptoms of a possible electrolyte imbalance, contact your healthcare provider. Some of these symptoms may include:
    • Dry mouth
    • Increased thirst
    • Weakness
    • Tiredness
    • Restlessness
    • Seizures
    • Confusion
    • Muscle pain and cramps
    • Decrease urine output
    • Weak or irregular heartbeat
    • Nausea and vomiting.
  • Hydrochlorothiazide (one of the active ingredients in aliskiren-amlodipine-hydrochlorothiazide) has been reported to worsen systemic lupus erythematosus or, in some cases, even to cause the condition.
  • Aliskiren-amlodipine-hydrochlorothiazide is a pregnancy Category D medication. This means that it is probably not safe for use during pregnancy, as it can increase the risk for birth defects and other severe problems (see Amturnide and Pregnancy).
  • It is known that hydrochlorothiazide passes through breast milk. However, it is unknown if the same is true for the other active ingredients in aliskiren-amlodipine-hydrochlorothiazide. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Amturnide and Breastfeeding).
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Aliskiren-Amlodipine-Hydrochlorothiazide Information

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