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Effects of Aliskiren-Amlodipine-Hydrochlorothiazide

How Does This Medicine Work?

As the name implies, aliskiren-amlodipine-hydrochlorothiazide contains three different medications. Amlodipine is a calcium channel blocker. It helps slow down the rate at which calcium moves into your blood vessel walls. This, in turn, relaxes the vessels, which improves blood flow and lowers blood pressure.
Aliskiren belongs to a class of drugs called renin inhibitors. Renin is an enzyme produced in the kidneys that acts throughout the body. It converts angiotensinogen to angiotensin I. A different enzyme (angiotensin-converting enzyme, or ACE) then converts angiotensin I to angiotensin II, a powerful substance that increases blood pressure by narrowing blood vessels and indirectly stimulating the kidneys to retain salt.
Hydrochlorothiazide is a diuretic, which is commonly referred to as a "water pill." It works by increasing the amount of salt and water the kidneys remove from the blood. This extra salt and water is then passed out through the urine. By increasing the amount of water removed from the blood, hydrochlorothiazide causes a decrease in blood volume. Because of this effect, hydrochlorothiazide can lower blood pressure and also help with water retention.

Can Children and Teens Use It?

Aliskiren-amlodipine-hydrochlorothiazide is not approved for use in children or teens. Talk with your child's healthcare provider about the benefits and risks of using this medicine in children.

Is Aliskiren-Amlodipine-Hydrochlorothiazide Used for Off-Label Reasons?

On occasion, healthcare providers may recommend medications for something other than the approved uses. This is known as an "off-label" use. At this time, there are no well-accepted off-label uses for aliskiren-amlodipine-hydrochlorothiazide.
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Aliskiren-Amlodipine-Hydrochlorothiazide Information

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