Hypertension Channel
Topics
Medications
Quicklinks
Related Channels

How Aliskiren/Amlodipine Works and What to Tell Your Doctor

Important Information for Your Healthcare Provider

You should talk with your healthcare provider prior to taking aliskiren/amlodipine if you have:
 
Also, let your healthcare provider know if you are:
 
Make sure to tell your healthcare provider about all medicines you are taking, including prescription and nonprescription medications, vitamins, and herbal supplements.
 
(Click Precautions and Warnings With Aliskiren/Amlodipine to learn more, including information on who should not take the drug.)
 

How Does Aliskiren/Amlodipine Work?

As mentioned, aliskiren/amlodipine contains two different medications, which work in the following ways:
 
  • Aliskiren is classified as a renin inhibitor and is the first medication of its kind. Renin is an enzyme produced in the kidneys that acts throughout the body. It works to convert angiotensinogen to angiotensin I. A different enzyme (angiotensin-converting enzyme or ACE) then converts angiotensin I to angiotensin II, a powerful substance that increases blood pressure by narrowing blood vessels and indirectly stimulating the kidneys to retain salt.
Several different blood pressure medications work in various steps in this process (such as ACE inhibitors or angiotensin II receptor blockers, known as ARBs). However, aliskiren is different; it acts at the very beginning of the process, preventing renin from converting angiotensinogen to angiotensin I (the first step in the process). 
Life After a Stent: 5 Realistic Ways to Take Charge of Your Health

Aliskiren/Amlodipine Drug Information

Terms of Use
Advertise with Us
Contact Us
About eMedTV
Privacy Policy
Copyright © 2006-2017 Clinaero, Inc.
eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind. Site users seeking medical advice about their specific situation should consult with their own physician. Click Terms of Use for more information.