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Precautions and Warnings With Aliskiren/Amlodipine

Women who are pregnant are typically warned against using aliskiren/amlodipine for the treatment of high blood pressure. Safety precautions also apply to women who are breastfeeding, people who are allergic to any of the ingredients in the drug, and people with heart or liver disease, among other things. Understanding these issues before you take aliskiren/amlodipine can help ensure a safe treatment process.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking aliskiren/amlodipine (Tekamlo™) if you have:
 
Also, let your healthcare provider know if you are:
 
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
     
Make sure to tell your healthcare provider about all medicines you may be taking, including prescription and nonprescription medications, vitamins, and herbal supplements.
 

Specific Aliskiren/Amlodipine Warnings and Precautions

Warnings and precautions to be aware of prior to taking aliskiren/amlodipine include the following:
 
  • Pregnant women should not take aliskiren/amlodipine. This drug is a renin inhibitor, and medications that affect the renin-angiotensin system have been shown to cause serious problems when used during pregnancy (see Tekamlo and Pregnancy for more information).
     
  • Aliskiren/amlodipine can cause angioedema, a life-threatening reaction involving swelling of the lips, mouth, tongue, or throat. If you experience such symptoms, seek medical attention right away.
     
  • As with all blood pressure medications, aliskiren/amlodipine may sometimes cause low blood pressure (hypotension). Let your healthcare provider know if you develop signs of low blood pressure, such as dizziness, lightheadedness, or fainting.
     
  • If you have severe heart disease, there is a small possibility that taking this drug may increase your chances of worsening chest pain or heart attack.
     
  • Medications like aliskiren/amlodipine should be used with caution in people with heart failure, who should be monitored carefully during treatment. Aliskiren/amlodipine can cause fluid retention, which can be especially dangerous for people with heart failure.
     
  • Make sure your healthcare provider knows if you have kidney or liver problems before you take this drug. Your healthcare provider may need to monitor you more closely, and in some situations aliskiren/amlodipine may not be the best choice for you.
     
  • Aliskiren/amlodipine can react with other medications (see Drug Interactions With Aliskiren/Amlodipine).
     
  • It is unknown if aliskiren/amlodipine passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Tekamlo and Breastfeeding).
     
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Aliskiren/Amlodipine Drug Information

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