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How Aliskiren/Amlodipine Works and Specific Uses

How Does Aliskiren/Amlodipine Work?

The two medications in aliskiren/amlodipine work in the following ways:
  • Aliskiren is classified as a renin inhibitor and is the first medication of its kind. Renin is an enzyme produced in the kidneys that acts throughout the body. It works to convert angiotensinogen to angiotensin I. A different enzyme (angiotensin-converting enzyme or ACE) then converts angiotensin I to angiotensin II, a powerful substance that increases blood pressure by narrowing blood vessels and indirectly stimulating the kidneys to retain salt.
Several different blood pressure medications work in various steps in this process (such as ACE inhibitors or angiotensin II receptor blockers, known as ARBs). However, aliskiren is different; it acts at the very beginning of the process, preventing renin from converting angiotensinogen to angiotensin I (the first step in the process). 

Can Children Use Aliskiren/Amlodipine?

Aliskiren/amlodipine is not approved for use in children. Other medications that have been around longer and have been studied in children may be better choices for treating high blood pressure in this age group.

Off-Label Uses

On occasion, your healthcare provider may recommend this product for something other than high blood pressure. However, there are currently no universally accepted off-label aliskiren/amlodipine uses.
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Aliskiren/Amlodipine Drug Information

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