More Info on Aliskiren and Valsartan Interactions
Aliskiren and valsartan can decrease your blood levels of furosemide, possibly making furosemide less effective. Your healthcare provider may need to adjust your furosemide dosage if you start (or stop) taking aliskiren and valsartan.
Cyclosporine (Gengraf, Neoral, Sandimmune)
Cyclosporine can greatly increase the level of aliskiren and valsartan in your blood. These medicines should not be taken together.
Itraconazole can greatly increase the level of aliskiren in your blood. These drugs should not be taken together.
Ketoconazole can increase the level of aliskiren and valsartan in the blood, which could increase your risk of side effects of aliskiren and valsartan. Your healthcare provider may need to adjust your aliskiren and valsartan dosage if you start (or stop) taking ketoconazole, although this may not be necessary in many cases.
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Aliskiren and valsartan can interact with NSAIDs in several ways. The combination could cause your blood pressure to increase or may cause swelling (edema), especially if you have congestive heart failure (CHF). If you are elderly, have kidney disease or kidney failure, or are taking a diuretic ("water pill") or are dehydrated, taking NSAIDs and this medication together may cause kidney failure. Talk to your healthcare provider about this potential drug interaction before taking these medications together.
Combining aliskiren and valsartan with potassium may increase your risk of high blood potassium (hyperkalemia), a dangerous problem. If you take these medications together, your healthcare provider should monitor your potassium levels.