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Specific Concerns With Aliskiren and Valsartan

Specific Aliskiren and Valsartan Warnings and Precautions

Some warnings and precautions to be aware of prior to taking aliskiren and valsartan include the following:
  • Pregnant women should not take this drug. Medications like aliskiren and valsartan have been shown to cause serious problems when used during pregnancy (see Valturna and Pregnancy for more information).
  • Aliskiren and valsartan can cause angioedema, a life-threatening reaction involving swelling of the lips, mouth, tongue, or throat. If you experience such symptoms, seek immediate medical attention.
  • Just like all blood pressure medications, aliskiren and valsartan may sometimes cause low blood pressure (hypotension). Let your healthcare provider know if you develop signs of low blood pressure, such as dizziness, lightheadedness, or fainting.


  • Sweating, dehydration (which could occur if you do not drink enough fluids), vomiting, and diarrhea could cause your blood pressure to lower to unsafe levels while taking aliskiren and valsartan. Stay hydrated by drinking plenty of fluids, and let your healthcare provider know if you develop these symptoms. In addition, any of these conditions, as well as taking a diuretic ("water pill"), may increase the risk of kidney failure due to this medication. 


  • Make sure your healthcare provider knows if you have kidney, liver, or heart problems before you take this medicine. Your healthcare provider may need to monitor you more closely, and in some situations, aliskiren and valsartan may not be the best choice for you.


  • This medication may cause a decrease in kidney function, especially in people who are elderly, have kidney disease, have severe congestive heart failure (CHF), or are taking nonsteroidal anti-inflammatory drugs (NSAIDs). Your healthcare provider may choose to monitor your kidney function with a blood test while you are taking aliskiren and valsartan. Contact your healthcare provider if you notice a decrease in urination or swelling in your hands, legs, ankles, or feet, which can be signs of kidney problems. 


  • In rare cases, aliskiren and valsartan causes high blood potassium (hyperkalemia). However, this may be more common if you already have elevated potassium levels or if you take certain medications that also increase potassium levels (see Drug Interactions With Aliskiren and Valsartan).
  • It is not known whether aliskiren and valsartan passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Valturna and Breastfeeding).
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Aliskiren and Valsartan Drug Information

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