Answers to Questions on Aliskiren
What If I Take an Overdose?It is not known what exactly to expect from an overdose with this medication. However, it is predicted that people who take too much will develop low blood pressure (hypotension).
If you happen to take too much aliskiren, seek immediate medical attention.
(Click Tekturna Overdose for more information.)
How Should Aliskiren Be Stored?Aliskiren tablets should be stored at room temperature, away from moisture and heat. Keep this and all other medications out of the reach of children.
What Should I Do If I Miss a Dose?If you forget to take a dose of aliskiren, take your missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose.
How Does It Work?Aliskiren is classified as a renin inhibitor. It is the first medication of its kind. Renin is an enzyme produced in the kidneys that acts throughout the body. It converts angiotensinogen to angiotensin I. A different enzyme (angiotensin-converting enzyme, or ACE) then converts angiotensin I to angiotensin II, a powerful substance that increases blood pressure by narrowing blood vessels and indirectly stimulating the kidneys to retain salt.
Various blood pressure medications work during different steps in this process (such as ACE inhibitors or angiotensin II receptor blockers, known as ARBs). However, aliskiren is different; it acts at the beginning of the process, preventing renin from converting angiotensinogen to angiotensin I.