More Aliskiren Interactions
Atorvastatin Products (Lipitor, Caduet)
Atorvastatin can increase the level of aliskiren in the blood by as much as 50 percent. This could increase your risk of side effects of aliskiren. Your healthcare provider may need to adjust your aliskiren dosage if you start or stop taking this drug, although this may not be necessary in all cases.
Aliskiren can decrease your blood levels of furosemide, possibly making furosemide less effective. Your healthcare provider may need to adjust your furosemide dosage if you start or stop taking aliskiren.
Cyclosporine (Gengraf, Neoral, Sandimmune)
Cyclosporine can greatly increase the level of aliskiren in your blood. These medications should not be taken together.
Itraconazole can greatly increase the level of aliskiren in your blood. These drugs should not be taken together.
Ketoconazole can increase the level of aliskiren in the blood, which could increase your risk of aliskiren side effects. Your healthcare provider may need to adjust your dose of aliskiren if you start or stop taking ketoconazole, although this may not be necessary in all cases.
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Aliskiren can interact with NSAIDs in several ways. The combination could cause your blood pressure to increase or may cause swelling (edema), especially if you have congestive heart failure (CHF). If you are elderly, have kidney disease or kidney failure, or are taking a diuretic ("water pill") or are dehydrated, taking NSAIDs and aliskiren together may cause kidney failure. Talk to your healthcare provider about this potential drug interaction before taking these medications together.
Products Containing Potassium
Combining aliskiren with potassium may increase your risk of high blood potassium (hyperkalemia), which can be a serious problem. If you take these substances together, your healthcare provider should monitor your potassium levels.