Important Instructions on Amlodipine and Atorvastatin
What Should I Tell My Healthcare Provider?You should talk with your healthcare provider prior to taking amlodipine and atorvastatin if you have:
- Liver disease, including liver failure, cirrhosis, or hepatitis
- Low blood pressure (hypotension)
- A severe infection
- Uncontrolled seizures
- A severe hormonal or electrolyte imbalance
- Major surgery or trauma
- A history of stroke or transient ischemic attack (TIA or "mini-stroke")
- Congestive heart failure (CHF)
- Kidney disease or kidney failure (renal failure)
- Any allergies, including allergies to food, dyes, or preservatives.
Make sure to tell your healthcare provider about all of the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Amlodipine and Atorvastatin to learn more, including information on who should not take the drug.)
How Does Amlodipine and Atorvastatin Work?Amlodipine is part of a class of drugs called calcium channel blockers. It helps slow down the rate at which calcium moves into your heart and blood vessel walls. This, in turn, helps to relax the vessels, which allows for better blood flow and causes lower blood pressure. It also makes it easier for the heart to pump blood.
The other component, atorvastatin, belongs to a group of medications called statins (or HMG-CoA reductase inhibitors). It works by blocking a particular enzyme -- HMG-CoA reductase -- that controls the rate of cholesterol production in the body. This causes the liver to make less cholesterol. Atorvastatin also:
- Increases the liver's ability to collect and get rid of LDL cholesterol ("bad cholesterol")
- Increases HDL cholesterol ("good cholesterol")
- Decreases triglycerides.