Theoretically, amlodipine and atorvastatin may decrease the level of steroid hormones in the body. Since cimetidine can also lower these hormone levels, taking these medications together can increase your risk of problems due to low hormones. Talk to your healthcare provider before combining cimetidine with amlodipine and atorvastatin.

Colchicine

There have been reports of myopathy or rhabdomyolysis possibly due to the combination of colchicine and atorvastatin. Colchicine and atorvastatin should be used together with caution.

Cyclosporine

Taking cyclosporine and amlodipine and atorvastatin simultaneously may increase your risk of side effects due to the atorvastatin (Lipitor) component, including serious muscle problems, such as myopathy or rhabdomyolysis. This combination of medications should be avoided. In addition, the amlodipine component can increase the level of cyclosporine in the bloodstream, increasing the risk for side effects.

Digoxin

Amlodipine and atorvastatin can increase the level of digoxin in your blood, perhaps increasing your risk of digoxin side effects. Your healthcare provider should monitor the level of digoxin in your blood and adjust your dose of this medication as necessary.

Diltiazem

Diltiazem may increase the level of atorvastatin in your blood, increasing your risk of side effects. Check with your healthcare provider before taking these medications together.

Efavirenz

Efavirenz may decrease the level of atorvastatin in your blood. Check with your healthcare provider before taking these medications together.

Fibrates

Taking a fibrate and amlodipine and atorvastatin at the same time may increase your risk of atorvastatin (Lipitor) side effects, including serious muscle problems, such as myopathy or rhabdomyolysis. Talk with your healthcare provider before combining these two medications.

Drug Interactions With Amlodipine and Atorvastatin Article Continues on Next Page >

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD

Last reviewed by: Kristi Monson, PharmD

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