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Why Are Interactions With Amlodipine and Atorvastatin Important?

Grapefruit Juice
Grapefruit juice can increase the level of the atorvastatin (Lipitor) component of amlodipine and atorvastatin (see Lipitor and Grapefruit). In general, it is a good idea to avoid grapefruit juice while you are taking the drug.
 
Niacin
Combining niacin with amlodipine and atorvastatin can increase the risk of serious muscle problems (such as myopathy or rhabdomyolysis), due to the atorvastatin (Lipitor) component of the drug. Talk with your healthcare provider before taking amlodipine and atorvastatin with niacin, including non-prescription niacin supplements.
 
Statins
Amlodipine and atorvastatin contains a statin medication. Therefore, combining it with other statin medications may increase the risk of serious muscle problems, such as myopathy or rhabdomyolysis. In general, you should not use more than one statin at the same time.
 
Protease Inhibitors
Taking amlodipine and atorvastatin with a protease inhibitor may increase the level of the atorvastatin (Lipitor) component in your blood. This can increase your risk of atorvastatin side effects, including serious muscle problems, such as myopathy or rhabdomyolysis. Depending on your individual situation, your healthcare provider may choose to monitor your progress closely and make necessary dosing adjustments.
 
Some protease inhibitors (particularly, telaprevir or the combination of tipranavir plus ritonavir) should never be combined with atorvastatin. The other protease inhibitors may be combined with atorvastatin with caution, and reduced maximum dosages of the atorvastatin may be recommended.
 
Red Yeast Rice
Red yeast rice is a supplement used to lower cholesterol. Taking it with amlodipine and atorvastatin may increase your risk of serious muscle problems, such as myopathy or rhabdomyolysis. In general, you should not use amlodipine and atorvastatin with red yeast rice.
 
Rifampin
Rifampin may decrease the level of atorvastatin in your blood. Check with your healthcare provider before taking these medications together.
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Amlodipine and Atorvastatin (Caduet) -- Drug Information

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