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Important Safety Concerns for Amlodipine and Atorvastatin

Specific Precautions and Warnings With Amlodipine and Atorvastatin

Warnings and precautions to be aware of prior to taking amlodipine and atorvastatin include the following:


  • In one study, atorvastatin (one of the components of Caduet) appeared to increase the risk of a stroke in people who had experienced a stroke or transient ischemic attack (TIA or "mini-stroke") within the previous six months. Talk with your healthcare provider about taking Caduet if you have a history of a stroke or TIA.

  • Statins (including atorvastatin, one of the components) have been known to cause an increase in liver enzymes, which can be a sign of liver damage. Therefore, healthcare providers typically recommend that you have a blood test to check your liver function before starting amlodipine and atorvastatin.

Previously it had been recommended that people taking statins have routine periodic liver function tests while taking the medication, but this recommendation has been removed since such monitoring does not help much to detect or prevent such problems. Liver function tests should still be performed if there is any suspicion of liver damage. 

  • Rhabdomyolysis (the severe breakdown of muscles) has been reported in rare cases with atorvastatin and other statins. This muscle damage can cause serious kidney damage. You are at greater risk for developing muscle problems with amlodipine and atorvastatin (and subsequent kidney damage) if you:
Make sure to contact your healthcare provider immediately if you experience any muscle pain, weakness, or tenderness, especially if it is accompanied by a fever or if you feel ill. 
  • Amlodipine and atorvastatin is considered a pregnancy Category X medication. This means that it is dangerous when used during pregnancy (see Caduet and Pregnancy).
  • It is not known if amlodipine and atorvastatin passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Caduet and Breastfeeding).
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Amlodipine and Atorvastatin (Caduet) -- Drug Information

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