Amlodipine and Olmesartan Interactions Explained
The following sections explain in detail the potentially negative interactions that can occur when
amlodipine and olmesartan is combined with any of the drugs listed above. Because the
amlodipine (
Norvasc®) component is unlikely to interact with most other medications, the interactions discussed in this article are primarily due to the
olmesartan (
Benicar®) component of amlodipine and olmesartan.
ACE Inhibitors
Angiotensin II receptor blockers (ARBs), such as olmesartan, may increase the level of potassium in the blood. Because ACE inhibitors also have this tendency, combining an ACE inhibitor with amlodipine and olmesartan could increase the risk of high blood potassium (hyperkalemia) in some people.
Amiloride (Midamor) or Amiloride-HCTZ (Moduretic)
Combining amlodipine and olmesartan with
amiloride products could increase your risk of high blood potassium. If your healthcare provider recommends taking these two medications together, your blood potassium levels should be closely monitored.
Angiotensin II Receptor Blockers (ARBs)
Amlodipine and olmesartan contains an ARB (olmesartan) and should generally not be combined with other ARBs, as this could increase the risk of high blood potassium or other side effects.
Eplerenone (Inspra)
Taking eplerenone with amlodipine and olmesartan could increase your risk of developing high levels of potassium in your blood. Your healthcare provider may need to monitor your potassium levels if you take these medications together.
Other Blood Pressure Medications
Combining amlodipine and olmesartan with other
high blood pressure medications may increase your risk of dangerously low
blood pressure (known medically as hypotension). Diuretics ("water pills") may especially cause this problem when taken with amlodipine and olmesartan.
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