Products That Interfere With Amlodipine and Olmesartan
Amlodipine and Olmesartan Interactions ExplainedThe following sections explain in detail the potentially negative interactions that can occur when amlodipine and olmesartan is combined with any of the drugs listed above.
Angiotensin II receptor blockers (ARBs), such as olmesartan, may increase the level of potassium in the blood. Because ACE inhibitors also have this tendency, combining an ACE inhibitor with amlodipine and olmesartan could increase the risk of high blood potassium (hyperkalemia) in some people.
Amiloride (Midamor) or Amiloride-HCTZ (Moduretic)
Combining amlodipine and olmesartan with amiloride products could increase your risk of high blood potassium. If your healthcare provider recommends taking these two medications together, your blood potassium levels should be closely monitored.
Angiotensin II Receptor Blockers (ARBs)
Amlodipine and olmesartan contains an ARB (olmesartan) and should generally not be combined with other ARBs, as this could increase the risk of high blood potassium or other side effects.
Colesevelam may decrease the absorption of amlodipine and olmesartan into the body, perhaps making it less effective. This interaction can be avoided by taking amlodipine and olmesartan at least four hours before colesevelam.
Amlodipine may increase the level of cyclosporine in the blood, perhaps increasing the risk for side effects. Because it is important for cyclosporine levels to fall within a certain range, your healthcare provider may need to check your blood levels and adjust your cyclosporine dosage if you start or stop taking amlodipine.