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Do Interactions With Amlodipine and Olmesartan Matter to Me?

Eplerenone (Inspra)
Taking eplerenone with amlodipine and olmesartan could increase your risk of developing high levels of potassium in your blood. Your healthcare provider may need to monitor your potassium levels if you take these medications together.
 
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Amlodipine and olmesartan can interact with NSAIDs in several ways. The combination could cause your blood pressure to increase or may cause swelling (edema), especially if you have congestive heart failure (CHF). If you are elderly, have kidney disease or kidney failure, or are taking a diuretic ("water pill") or are dehydrated, taking NSAIDs and amlodipine and olmesartan together may cause kidney failure. Talk to your healthcare provider about this potential drug interaction before taking these medications together.
  
Other Blood Pressure Medications
Combining amlodipine and olmesartan with other high blood pressure medications may increase your risk of dangerously low blood pressure (known medically as hypotension). Diuretics ("water pills") may especially cause this problem when taken with amlodipine and olmesartan.
 
Potassium
Amlodipine and olmesartan may potentially increase your potassium level. If you are taking potassium (to treat low potassium levels), your potassium dose may need to be lowered, or you may need to stop taking potassium altogether. Check with your healthcare provider before combining amlodipine and olmesartan with any potassium product.
 
Simvastatin
Amlodipine and olmesartan increases the level of simvastatin in the blood, increasing the risk of serious side effects of simvastatin. If these medications are combined, the simvastatin dosage should not exceed 20 mg per day.
  
Spironolactone (Aldactone) or Spironolactone-HCTZ (Aldactazide)
Combining amlodipine and olmesartan with spironolactone products could increase your risk of high blood potassium. If your healthcare provider recommends taking these two medications together, your blood potassium levels should be closely monitored.
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Amlodipine and Olmesartan Information

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