Amlodipine and olmesartan is used for treating high blood pressure in adults (age 18 and older). It is a combination medication and helps to lower blood pressure by relaxing the blood vessels. By lowering blood pressure, amlodipine and olmesartan can decrease the risk of developing health problems, such as a stroke, heart disease, or congestive heart failure, which can occur with long-term high blood pressure. There are currently no off-label amlodipine and olmesartan uses.