Drug Interactions With Amlodipine and Valsartan

Amlodipine and Valsartan Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when amlodipine and valsartan is combined with any of the drugs listed above.
 
ACE Inhibitors
Combining amlodipine and valsartan with ACE inhibitors can increase your risk of high potassium levels in your blood (hyperkalemia). Your healthcare provider should check your potassium levels regularly (see Exforge and High Potassium for more information).
 
Alcohol
Drinking alcohol while taking amlodipine and valsartan can increase your risk of low blood pressure, especially when sitting or standing up suddenly. Talk to your healthcare provider about combining alcohol with amlodipine and valsartan.
 
Amiloride (Midamor) or Amiloride-HCTZ (Moduretic)
Amlodipine and valsartan may interact with amiloride. Taking these two medications together increases your risk of high potassium levels (hyperkalemia).
 
Angiotensin II Receptor Blockers (ARBs)
Combining amlodipine and valsartan with ARBs can increase your risk of high potassium levels in your blood (hyperkalemia). Your healthcare provider should check your potassium levels regularly.
 
Digoxin (Digitek, Lanoxin)
Amlodipine and valsartan should be used carefully in people taking digoxin. Amlodipine and valsartan can cause high potassium levels (hyperkalemia), which can be especially dangerous for people taking digoxin.
 
Eplerenone (Inspra)
Combining amlodipine and valsartan with eplerenone inhibitors can increase your risk of high potassium levels in your blood (hyperkalemia). Your healthcare provider should check your potassium levels regularly.
(Drug Interactions With Amlodipine and Valsartan Continued: Page 3)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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