More Info on Amlodipine and Valsartan Interactions
Digoxin (Digitek, Lanoxin)
Amlodipine and valsartan should be used carefully in people taking digoxin. Amlodipine and valsartan can cause high potassium levels (hyperkalemia), which can be especially dangerous for people taking digoxin.
Combining amlodipine and valsartan with eplerenone inhibitors can increase your risk of high potassium levels in your blood (hyperkalemia). Your healthcare provider should check your potassium levels regularly.
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Amlodipine and valsartan can interact with NSAIDs in several ways. The combination could cause your blood pressure to increase or may cause swelling (edema), especially if you have congestive heart failure (CHF). If you are elderly, have kidney disease or kidney failure, or are taking a diuretic ("water pill") or are dehydrated, taking NSAIDs and amlodipine and valsartan together may cause kidney failure. Talk to your healthcare provider about this potential drug interaction before taking these medications together.
In general, potassium-containing products should not be used with amlodipine and valsartan, due to the risk of high potassium levels (hyperkalemia).
Amlodipine increases the level of simvastatin in the blood, increasing the risk of serious side effects of simvastatin. If these medications are combined, the simvastatin dosage should not exceed 20 mg per day.
Combining amlodipine and valsartan with medications that contain triamterene can increase your risk of high potassium levels in your blood (hyperkalemia). Your healthcare provider should check your potassium levels regularly.