Hypertension Channel
Topics
Medications
Quicklinks
Related Channels

Precautions and Warnings With Amlodipine-Valsartan-Hydrochlorothiazide

There are many precautions and warnings to be aware of with amlodipine-valsartan-hydrochlorothiazide. For example, you should let your healthcare provider know if you have kidney disease, congestive heart failure, or an electrolyte imbalance before starting treatment, as this drug may cause problems in people with these conditions. You should avoid taking the product altogether if you are allergic to sulfa drugs.

What Should I Tell My Healthcare Provider Before Taking Amlodipine-Valsartan-Hydrochlorothiazide?

You should talk with your healthcare provider prior to taking amlodipine-valsartan-hydrochlorothiazide (Exforge HCT®) if you have:
 
Also, let your healthcare provider know if you are:
 
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
     
Make sure to tell your healthcare provider about all other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
 

Specific Precautions and Warnings

Some warnings and precautions to be aware of prior to taking amlodipine-valsartan-hydrochlorothiazide include the following:
 
  • Amlodipine-valsartan-hydrochlorothiazide is considered a pregnancy Category D medication. This means that it is probably not safe for use during pregnancy. Amlodipine-valsartan-hydrochlorothiazide can increase the risk of birth defects and other severe problems (see Exforge HCT and Pregnancy).
     
  • Amlodipine-valsartan-hydrochlorothiazide can lower your blood pressure too much. Signs of low blood pressure include lightheadedness, dizziness, or fainting. Congestive heart failure, a recent heart attack, or surgery can increase your risk of low blood pressure.
     
  • If you have liver disease, your body may not metabolize amlodipine-valsartan-hydrochlorothiazide as well as it should. Therefore, you may require extra monitoring by your healthcare provider, and you may need to take a lower amlodipine-valsartan-hydrochlorothiazide dosage.
     
  • Drugs that contain hydrochlorothiazide (including this medication) can sometimes cause a potentially dangerous eye reaction (a particularly dangerous type of glaucoma). This reaction usually occurs within days to weeks of starting the drug. 
Because this reaction can permanently damage vision, let your healthcare provider know right away if you develop vision changes and/or eye pain. The main treatment for this reaction is to stop taking this medication, although other treatment (including surgery) may sometimes be necessary.
  • This medication may cause a decrease in kidney function, especially in people who are elderly, have kidney disease, have severe congestive heart failure (CHF), or are taking nonsteroidal anti-inflammatory drugs (NSAIDs) or diuretics (water pills). Your healthcare provider may choose to monitor your kidney function with a blood test while you are taking it. 
Contact your healthcare provider if you notice a decrease in urination or swelling in your hands, legs, ankles, or feet, which can be signs of kidney problems.
  • If you have severe coronary artery disease, there is a low possibility that taking amlodipine-valsartan-hydrochlorothiazide may increase your chances of worsening chest pain or heart attack.
     
  • Amlodipine-valsartan-hydrochlorothiazide has not been studied in people with heart failure. Medications like amlodipine-valsartan-hydrochlorothiazide should be used with caution (and extra monitoring) in people with heart failure.
     
  • People with asthma have an increased risk of an allergy to hydrochlorothiazide, one of the active ingredients in amlodipine-valsartan-hydrochlorothiazide.
     
  • Amlodipine-valsartan-hydrochlorothiazide can interact with a number of other medications (see Drug Interactions With Amlodipine-Valsartan-Hydrochlorothiazide for more information).
     
  • It is known that hydrochlorothiazide passes through breast milk. It is unknown if the same is true for the other active ingredients in amlodipine-valsartan-hydrochlorothiazide. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Exforge HCT and Breastfeeding).
     
  • Amlodipine-valsartan-hydrochlorothiazide may affect electrolytes in the blood (including sodium, calcium, potassium, magnesium, and chloride). Therefore, your healthcare provider will regularly check these levels. If you notice any symptoms of a possible electrolyte imbalance, contact your healthcare provider. These symptoms may include:

 

    • Dry mouth and increased thirst
    • Weakness
    • Tiredness
    • Restlessness
    • Seizures
    • Confusion
    • Muscle pain and cramps
    • Decreased urine output
    • Weak or irregular heartbeat
    • Nausea and vomiting.

 

  • Hydrochlorothiazide (one of the active ingredients in amlodipine-valsartan-hydrochlorothiazide) has been reported to worsen systemic lupus erythematosus or, in some cases, to even cause the condition.
     
Ways to Prep Your Kitchen to Eat Well During Cancer Treatment

Amlodipine-Valsartan-Hydrochlorothiazide Information

Referring Pages:
Terms of Use
Advertise with Us
Contact Us
About eMedTV
Privacy Policy
Copyright © 2006-2017 Clinaero, Inc.
eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind. Site users seeking medical advice about their specific situation should consult with their own physician. Click Terms of Use for more information.