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Drug Interactions With Azilsartan/Chlorthalidone

Angiotensin II Receptor Blockers (ARBs)
Combining azilsartan/chlorthalidone (which contains an ARB) with another ARB may increase the risk for certain side effects, such as high blood potassium, kidney problems, or significantly low blood pressure. In general, azilsartan/chlorthalidone should not be combined with another ARB.
Taking a barbiturate with azilsartan/chlorthalidone may cause your blood pressure to lower too much. Talk to your healthcare provider about this potential interaction before taking these drugs together.
Taking corticosteroids with azilsartan/chlorthalidone could cause low blood potassium levels (hypokalemia) or other electrolyte problems. If you take these medications together, your healthcare provider may monitor your blood electrolyte levels more closely.
Diabetes Medications
Using azilsartan/chlorthalidone with medications used to treat diabetes may increase blood sugar levels. If you take these medications together, your healthcare provider may monitor you more closely and may need to adjust the dose of your diabetes medication.
If you take azilsartan/chlorthalidone with eplerenone, the level of potassium in your blood may become too high. Your healthcare provider may choose to monitor your blood potassium level if you take these medications together. However, this interaction is somewhat unpredictable, as the two components of azilsartan/chlorthalidone tend to counteract each other in terms of effects on potassium.
Azilsartan/chlorthalidone may increase blood lithium levels, potentially causing lithium toxicity. Your healthcare provider may choose to monitor your blood lithium levels when you first start azilsartan/chlorthalidone. You may need a lower lithium dosage. Contact your healthcare provider right away if you have symptoms of toxicity, such as confusion, tremor, and incoordination, while taking these medications together.
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Azilsartan/Chlorthalidone Drug Information

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