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More Info on Interactions With Azilsartan/Chlorthalidone

Nonsteroidal Anti-inflammatory Drugs (NSAIDs)
Azilsartan/chlorthalidone can interact with NSAID medications in several ways. The combination could cause your blood pressure to increase or may cause swelling (edema), especially if you have congestive heart failure (CHF). If you have kidney disease or kidney failure, taking both NSAIDs and azilsartan/chlorthalidone may further damage your kidneys. Talk to your healthcare provider about the potential interaction before taking these drugs together.
 
Other Blood Pressure Medications
When taking azilsartan/chlorthalidone with another high blood pressure medication, your blood pressure may decrease too much. Your healthcare provider may monitor your blood pressure more closely and change the dose of one your medications if your blood pressure lowers too much.
 
Pentoxifylline
Taking azilsartan/chlorthalidone with pentoxifylline may cause your blood pressure to lower too much. Your healthcare provider may choose to monitor your blood pressure more closely if you take these medications together.
 
Potassium-Containing Products
If you take potassium products with azilsartan/chlorthalidone, your blood potassium levels may become too high. Check with your healthcare provider before combining azilsartan/chlorthalidone with any potassium product. However, this interaction is somewhat unpredictable, as the two components of azilsartan/chlorthalidone tend to counteract each other in terms of effects on potassium. Some people taking azilsartan/chlorthalidone may develop low potassium levels, requiring treatment with potassium supplements.
 
Potassium-Sparing Diuretics
Combining azilsartan/chlorthalidone with potassium-sparing diuretics could increase your risk of high blood potassium (hyperkalemia). It could also cause your blood pressure to become too low. Talk to your healthcare provider about this potential interaction before taking these drugs together. However, this interaction is somewhat unpredictable, as the two components of azilsartan/chlorthalidone tend to counteract each other in terms of effects on potassium.
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Azilsartan/Chlorthalidone Drug Information

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