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How Does Azilsartan/Chlorthalidone Lower Blood Pressure?

How Does This Medicine Work?

The chlorthalidone component of this product is a diuretic ("water pill"). It works by removing excess salt and water from the body. The extra salt and water are removed from the body by the kidneys and pass out through the urine. The removal of salt and water decreases blood volume, resulting in lower blood pressure.
 
The other component, azilsartan, belongs to a class of drugs called angiotensin II receptor blockers (ARBs). Angiotensin II is a naturally occurring chemical in the body that causes blood vessels to narrow (constrict). By blocking angiotensin II, azilsartan helps to relax the blood vessels, thereby lowering blood pressure.
 

Can Children Use Azilsartan/Chlorthalidone?

Azilsartan/chlorthalidone is not approved for use in children (normally defined as people younger than 18 years of age). It is not known if this medicine is safe or effective in this age group.
 

Is It Safe for Use in Older Adults?

Older adults can use this medication. However, they may be more sensitive to the effects of the medication, and therefore may need lower doses.
 

Is Azilsartan/Chlorthalidone Used for Off-Label Reasons?

On occasion, healthcare providers may recommend medications for something other than the approved uses. This is called an "off-label" use. At this time, there are no well-accepted off-label azilsartan/chlorthalidone uses.
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Azilsartan/Chlorthalidone Drug Information

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