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Why Interactions With Azilsartan Matter

Nonsteroidal Anti-inflammatory Drugs (NSAIDs)
Azilsartan can interact with NSAIDs in several ways. The combination could cause your blood pressure to increase or may cause swelling (edema), especially if you have congestive heart failure (CHF). If you have kidney disease or kidney failure, taking NSAIDs and azilsartan together may further damage your kidneys. Talk to your healthcare provider about this potential drug interaction before taking these medications together.
 
Pentoxifylline
Taking azilsartan with pentoxifylline may lower your blood pressure to unsafe levels. Your healthcare provider may choose to monitor your blood pressure more closely if you take these medications together.
 
Potassium-Containing Products
If you take potassium products with azilsartan, your blood potassium levels may become too high. Check with your healthcare provider before combining azilsartan with any potassium product.
 
Potassium-Sparing Diuretics
Combining azilsartan with potassium-sparing diuretics could increase your risk for high blood potassium (hyperkalemia). It could also lower your blood pressure to unsafe levels. Talk to your healthcare provider before taking these medications together.
 
Tolvaptan
Combining azilsartan with tolvaptan could increase your risk for high blood potassium (hyperkalemia). Your healthcare provider may want to monitor your blood potassium levels if you take these medications together.
 
Trimethoprim
Combining azilsartan with trimethoprim or a medication containing trimethoprim could increase your risk for high blood potassium (hyperkalemia). Your healthcare provider may want to monitor your blood potassium levels if you take these medications together.
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