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Effects of Benazepril-Amlodipine

How Does Benazepril-Amlodipine Work?

Benazepril-amlodipine is a combination of two medicines -- benazepril hydrochloride (sold under the brand Lotensin® and in generic form as Benazepril Hydrochloride) and amlodipine besylate (sold under the brand name Norvasc®). Lotensin is part of a class of drugs called angiotensin-converting enzyme inhibitors, or ACE inhibitors for short. Lotensin helps to block the angiotensin-converting enzyme, which is normally a part of a reaction in the body that causes the blood vessels to narrow (constrict). By blocking this enzyme, Lotensin causes blood vessels to relax.
Norvasc is part of a class of drugs called calcium channel blockers. Norvasc helps to slow down the rate at which calcium moves into your blood vessel walls. This, in turn, helps to relax the vessels, causing a decrease in blood pressure. It also makes it easier for the heart to pump blood.
Because of the effects of both Lotensin and Norvasc, benazepril-amlodipine can lower blood pressure. Because of its combined effects, benazepril-amlodipine causes a greater drop in blood pressure than when either medicine is used alone.

Effects of Benazepril-Amlodipine

A blood pressure reading consists of two numbers -- for example: 120/80. The top number is known as the systolic blood pressure and the bottom number is the diastolic blood pressure. During clinical studies in people taking benazepril-amlodipine, systolic blood pressure (the top number) decreased by up to 25 mmHg and diastolic blood pressure (the bottom number) decreased by up to 13 mmHg. The higher the dose of benazepril-amlodipine, the greater the drop in blood pressure tended to be.
By lowering blood pressure, benazepril-amlodipine can decrease the risk of developing health problems, (such as a heart attack or stroke) that can result from long-term high blood pressure (see Effects of High Blood Pressure).
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Benazepril-Amlodipine (Lotrel)

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