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Risks of Benazepril-Amlodipine

Some Benazepril-Amlodipine Warnings and Precautions

Some benazepril-amlodipine warnings and precautions to be aware of include:
  • There are a number of medicines that benazepril-amlodipine can interact with (see Drug Interactions With Benazepril-Amlodipine).
  • Benazepril-amlodipine is more likely than other drugs to cause allergic reactions. For example, there have been reports of severe allergic reactions occurring in people on benazepril-amlodipine during dialysis. There have also been reports of severe reactions in people getting bee or wasp venom to protect against stings.
Make sure to discuss these risks with your healthcare provider. Also, seek emergency medical attention immediately if you notice things such as hives, an unexplained rash, difficulty breathing, or swelling of the face or throat.
  • Medicines (like benazepril-amlodipine) that contain an ACE inhibitor may cause swelling (angioedema) of the head and neck, including the tongue, lips, eyes, or throat. This occurs more frequently in African Americans than in Caucasians. Seek emergency medical care immediately if you notice swelling in the head or neck area, wheezing, or difficulty breathing or swallowing.
  • In addition to head and neck angioedema, medicines like benazepril-amlodipine have been known to cause swelling in the intestines. This is known as intestinal angioedema. Symptoms may include stomach pain (with or without vomiting). Seek medical attention immediately if you develop any of these symptoms.
  • Benazepril-amlodipine may cause extremely low blood pressure in some people. Extremely low blood pressure is more likely to happen when the medicine is first started or the dosage is changed. It is also more likely to happen in people who are taking a diuretic, who are on dialysis, who have congestive heart failure, who have diarrhea or vomiting, or who have excessive sweating. This is why it is important to drink fluids regularly while taking benazepril-amlodipine. If you have any possible symptoms of low blood pressure (such as dizziness, lightheadedness, or fainting), contact your healthcare provider. If you have fainted, stop taking benazepril-amlodipine until you have talked to your healthcare provider.
Also, make sure not to drive, operate any heavy machinery, or perform any other tasks that require alertness before you know how benazepril-amlodipine affects you.
  • Benazepril-amlodipine is a pregnancy Category D medicine, meaning that benazepril-amlodipine poses clear health risks to your unborn child. Let your healthcare provider know if you are pregnant or thinking of becoming pregnant. If you become pregnant while taking benazepril-amlodipine, contact your healthcare provider immediately (see Lotrel and Pregnancy for more information).
  • Medicines (like benazepril-amlodipine) that contain an ACE inhibitor are known to cause a cough. If a cough becomes bothersome, talk to your healthcare provider about alternate options for your condition (see Lotrel Cough).
  • While taking benazepril-amlodipine, do not use potassium supplements or salt substitutes with potassium unless you have discussed this with your doctor. This is because in some people taking benazepril-amlodipine, potassium in the blood can increase to dangerous levels. High potassium in the blood may cause signs or symptoms that include muscle weakness; numbness in the feet or hands; nausea; an irregular heartbeat; or a slow, weak, or absent pulse.
  • People on benazepril-amlodipine can be at an increased risk of infections. Talk to your healthcare provider if you develop any symptoms that might indicate an infection, such as a sore throat or fever.
  • Medicines like benazepril-amlodipine have been known to cause a decrease in kidney function, especially in certain groups (such as those with severe congestive heart failure). Let your healthcare provider know if you have symptoms such as a decrease in urine output, drowsiness, headache, or back pain. Your healthcare provider will also regularly check your kidney function with a blood test.
  • In clinical studies, medicines that contain an ACE inhibitor, including benazepril-amlodipine, have rarely been known to cause liver failure. Contact your healthcare provider immediately if you notice things such as nausea, tiredness, lethargy, itchy or yellowing skin, abdominal pain, or flu-like symptoms.
  • If you have moderate to severe liver disease (such as cirrhosis), your body may metabolize the benazepril-amlodipine differently than intended. Therefore, your healthcare provider may start you on a lower dose of benazepril-amlodipine and will monitor your situation more closely, or may recommend another blood pressure medicine.
  • If you have severe coronary artery disease (also known as heart disease), there is a low possibility that taking Norvasc may increase your chances of worsening angina and/or a heart attack when starting Norvasc therapy or increasing your dose.
  • If you are nursing, certain parts of benazepril-amlodipine can pass through your breast milk. Therefore, if you are nursing, talk with your healthcare provider about whether you should stop taking benazepril-amlodipine or stop breastfeeding.
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