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Effects of Benazepril-Hydrochlorothiazide Interactions

More Detail About Benazepril-Hydrochlorothiazide Interactions

The following sections explain in detail the potentially negative interactions that can occur when benazepril-hydrochlorothiazide is combined with any of the drugs listed above.
 
Aliskiren
Combining benazepril-hydrochlorothiazide with aliskiren may increase the risk of dangerously low blood pressure (hypotension), fainting, kidney problems (including kidney failure), and dangerously high potassium levels in the blood (hyperkalemia). In general, such combinations are usually avoided. If it is necessary to take such medications together, very close monitoring will be required.
 
Aliskiren and benazepril-hydrochlorothiazide should never be combined in people with diabetes, because they may have a higher risk for these complications. Also, this combination is not recommended for people with moderate to severe kidney problems.   
 
Angiotensin II Receptor Blockers (ARBs)
Combining benazepril-hydrochlorothiazide with an ARB may increase the risk of dangerously low blood pressure (hypotension), fainting, kidney problems (including kidney failure), and dangerously high potassium levels in the blood (hyperkalemia). In general, such combinations are usually avoided. If it is necessary to take such medications together, very close monitoring will be required.
 
Diuretics
When taking benazepril-hydrochlorothiazide with a diuretic, your blood pressure may decrease too much. This is more likely to occur when benazepril-hydrochlorothiazide is first started. In order to decrease the chances of this interaction, your healthcare provider may change the dose of medicine, start you on a lower dose of benazepril-hydrochlorothiazide, and/or monitor you more closely.
 
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Benazepril-hydrochlorothiazide can interact with NSAIDs in several ways. The combination could cause your blood pressure to increase or may cause swelling (edema), especially if you have congestive heart failure (CHF). If you are elderly, have kidney disease or kidney failure, or are taking a diuretic ("water pill") or are dehydrated, taking NSAIDs and benazepril-hydrochlorothiazide together may cause kidney failure. Talk to your healthcare provider about this potential drug interaction before taking these medications together.
  
Potassium Supplements or Salt Substitutes With Potassium
If you are taking benazepril-hydrochlorothiazide along with a potassium supplement or a salt substitute with potassium, the levels of potassium in your blood may become too high. This can cause serious problems. For your particular situation, talk to your healthcare provider about using potassium and benazepril-hydrochlorothiazide together.
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