Hypertension Channel
Related Channels

Important Safety Concerns With Benazepril-Hydrochlorothiazide

Some Benazepril-Hydrochlorothiazide Warnings and Precautions

Some benazepril-hydrochlorothiazide warnings and precautions to be aware of include:
  • There are a number of medicines that benazepril-hydrochlorothiazide can interact with (see Drug Interactions With Benazepril-Hydrochlorothiazide).
  • Benazepril-hydrochlorothiazide is more likely than other drugs to cause allergic reactions. For example, there have been reports of severe allergic reactions occurring in people who were taking benazepril-hydrochlorothiazide during dialysis. There have also been reports of severe reactions in people getting bee or wasp venom to protect against stings. Finally, people with a history of asthma or allergies are more likely to have an allergic reaction to benazepril-hydrochlorothiazide.
Make sure to discuss these risks with your healthcare provider. Also, seek emergency medical attention immediately if you notice things such as hives, an unexplained rash, difficulty breathing, or swelling of the face or throat.
  • Medicines (like benazepril-hydrochlorothiazide) that contain an ACE inhibitor may cause swelling (angioedema) of the head and neck, including the tongue, lips, eyes, or throat. This occurs more frequently in African Americans than in Caucasians. Seek emergency medical care immediately if you notice any wheezing, swelling in the head or neck area, or if you have difficulty breathing or swallowing.
  • In addition to head and neck angioedema, medicines like benazepril-hydrochlorothiazide have been known to cause swelling in the intestines. This is known as intestinal angioedema. Symptoms may include stomach pain with or without vomiting. Seek medical attention immediately if you develop any of these symptoms.
  • Benazepril-hydrochlorothiazide may cause extremely low blood pressure in some people. Extremely low blood pressure is more likely to happen when the medicine is first started or the dosage is changed. It is also more likely to happen in people who are taking a diuretic, who are on dialysis, who have congestive heart failure, who have diarrhea or vomiting, or who have excessive sweating. This is why it is important to drink fluids regularly while taking benazepril-hydrochlorothiazide. If you have any possible symptoms of low blood pressure (such as dizziness, lightheadedness, or fainting), contact your healthcare provider. If you have fainted, stop taking benazepril-hydrochlorothiazide until you have talked to your healthcare provider.
Also, make sure not to drive, operate any heavy machinery, or perform any other tasks that require alertness before you know how benazepril-hydrochlorothiazide affects you.
  • Benazepril-hydrochlorothiazide is a pregnancy Category D medicine, meaning that benazepril-hydrochlorothiazide poses clear health risks to your unborn child. Let your healthcare provider know if you are pregnant or thinking of becoming pregnant. If you become pregnant while taking benazepril-hydrochlorothiazide, contact your healthcare provider immediately (see Lotensin HCT and Pregnancy).
  • Medicines (like benazepril-hydrochlorothiazide) that contain an ACE inhibitor are known to cause a cough. If a cough becomes bothersome, talk to your healthcare provider about other treatment options for your condition (see Lotensin Cough).
  • While taking benazepril-hydrochlorothiazide, do not use potassium supplements or salt substitutes with potassium unless you have discussed this with your doctor. This is because in some people taking benazepril-hydrochlorothiazide, potassium in the blood can increase or decrease to dangerous levels.
  • People on benazepril-hydrochlorothiazide can be at an increased risk of infections. Talk to your healthcare provider if you develop any symptoms (such as a sore throat or fever) that might suggest an infection.
  • This medication may cause a decrease in kidney function, especially in people who are elderly, have kidney disease, have severe congestive heart failure (CHF), or are taking nonsteroidal anti-inflammatory drugs (NSAIDs) or diuretics (water pills). Your healthcare provider may choose to monitor your kidney function with a blood test while you are taking it. 
Contact your healthcare provider if you notice a decrease in urination or swelling in your hands, legs, ankles, or feet, which can be signs of kidney problems. 
  • In clinical studies, medicines that contain an ACE inhibitor, including benazepril-hydrochlorothiazide, have been known to rarely cause liver failure. Contact your healthcare provider immediately if you notice things such as nausea, tiredness, lethargy, itchy or yellowing skin, abdominal pain, or flu-like symptoms.


  • Drugs that contain hydrochlorothiazide, including this medication, can sometimes cause a potentially dangerous eye reaction (a particularly dangerous type of glaucoma). This reaction usually occurs within days to weeks of starting the drug. 

Because this reaction can permanently damage vision, let your healthcare provider know right away if you develop vision changes and/or eye pain. The main treatment for this reaction is to stop taking this medication, although other treatment (including surgery) may sometimes be necessary. 

  • If you have moderate to severe liver disease (such as cirrhosis), your body may metabolize the benazepril-hydrochlorothiazide differently than intended. Therefore, your healthcare provider may start you on a lower dose of benazepril-hydrochlorothiazide and will monitor your situation more closely, or may recommend another blood pressure medicine altogether.
  • Benazepril-hydrochlorothiazide may affect electrolytes in the blood (including sodium, potassium, magnesium, and chloride). Therefore, your healthcare provider will regularly check these levels. If you notice any symptoms of a possible electrolyte imbalance, contact your healthcare provider. These symptoms may include a dry mouth, increased thirst, weakness, tiredness, restlessness, seizures, confusion, muscle pain or cramps, decrease in urine output, weak or irregular heartbeat, nausea, or vomiting.
  • Because of the hydrochlorothiazide, benazepril-hydrochlorothiazide is more likely to worsen systemic lupus erythematosus or, in some cases, even cause the condition.
  • Because of the hydrochlorothiazide, benazepril-hydrochlorothiazide is also known to worsen gout.
  • Benazepril-hydrochlorothiazide may cause high blood sugar (hyperglycemia) in diabetics or, in some cases, even cause diabetes in people without a history of the condition.
  • Benazepril-hydrochlorothiazide may increase levels of cholesterol and triglycerides in the blood.
  • If you are nursing, certain parts of benazepril-hydrochlorothiazide can pass through your breast milk. Therefore, if you are nursing, talk with your healthcare provider about whether you should stop taking benazepril-hydrochlorothiazide or stop breastfeeding.
Ouch! 6 Types of Pain You Might Experience When Getting a Stent

Benazepril HCT

Terms of Use
Advertise with Us
Contact Us
About eMedTV
Privacy Policy
Copyright © 2006-2019 Clinaero, Inc.
eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind. Site users seeking medical advice about their specific situation should consult with their own physician. Click Terms of Use for more information.