How Does Candesartan-Hydrochlorothiazide Work?
Candesartan-hydrochlorothiazide is a combination of two medicines --
candesartan and
hydrochlorothiazide. Candesartan is a newer type of
blood pressure medicine known as an angiotensin II receptor blocker, or ARB for short. Candesartan blocks angiotensin II receptors, thus decreasing the effectiveness of a chemical known as angiotensin II, which normally causes blood vessels to narrow (constrict). By blocking the effects of angiotensin II, candesartan causes blood vessels to relax.
Hydrochlorothiazide is a diuretic, which is commonly referred to as a "water pill." It works by increasing the amount of salt and water the kidneys remove from the blood. This extra salt and water is passed out through the urine. By increasing the amount of water removed from the blood, hydrochlorothiazide causes a decrease in blood volume.
Because of the effects of both candesartan and hydrochlorothiazide, candesartan-hydrochlorothiazide can
lower blood pressure. Because of its combined effects, candesartan-hydrochlorothiazide causes a greater drop in
blood pressure than when either medicine is used alone.
Candesartan-Hydrochlorothiazide Uses in Children
Candesartan-hydrochlorothiazide has not been approved for use in children.
Off-Label Candesartan-Hydrochlorothiazide Uses
On occasion, a healthcare provider may recommend candesartan-hydrochlorothiazide for treating a condition other than those listed above. This is called an "
off-label" use. At this time, there are no universally accepted off-label candesartan-hydrochlorothiazide uses.
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