Cardizem LA and Depression

In clinical studies where side effects were documented with Cardizem LA, depression was reported, although infrequently. Since less than 2 percent of people developed depression in these studies, it is difficult to determine if this side effect was actually caused by the medication or other factors. If you are taking Cardizem LA and depression symptoms occur, talk to your healthcare provider immediately.

 

Cardizem LA and Depression: An Overview

Cardizem LA® (diltiazem hydrochloride) is a prescription medication known as a calcium channel blocker. It is used to treat high blood pressure (hypertension) and chest pain (known medically as angina).
 
Just like any other medicine, side effects are possible with Cardizem LA. One of these possible side effects is depression.
 

Cardizem LA and Depression: How Common Is It?

The safety and effectiveness of diltiazem (the active ingredient of Cardizem LA) has been studied in thousands of people. In these clinical trials, less than 2 percent of people reported depression as a diltiazem side effect.
 
The challenge with Cardizem LA and depression is that given how uncommon depression is reported with diltiazem products and how common it is within the general population, it is difficult to tell whether depression is caused by Cardizem LA, other factors, or a combination of both.
 

Cardizem LA and Depression: Recommendations

For people taking Cardizem LA, depression may occur. Therefore, if you notice any possible depression symptoms while taking the drug, or if something "just does not seem right," you should talk to your healthcare provider. He or she will be able to diagnose and treat the problem. If your healthcare provider believes the medicine may be causing your symptoms, he or she may recommend another angina or blood pressure medicine.
 
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;