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Cardizem LA and Pregnancy

Animal studies on Cardizem LA and pregnancy show that the drug may not be safe for pregnant women. When the medication was given to pregnant mice, rats, and rabbits, it caused birth defects and miscarriages. Animals do not always respond to medicines the same way that humans do, but healthcare providers should only prescribe Cardizem LA during pregnancy if the benefits outweigh any possible risks.

Cardizem LA and Pregnancy: An Overview

Cardizem LA® (diltiazem hydrochloride) may not be safe for women who are pregnant. This is based on animal studies that looked at the effects of the drug during pregnancy.

Cardizem LA and Pregnancy Category C

The U.S. Food and Drug Administration (FDA) uses a category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. Pregnancy Category C is given to medicines that have not been studied in pregnant humans but that do appear to cause harm to the fetus in animal studies. Also, medicines that have not been studied in any pregnant women or animals are automatically given a pregnancy Category C rating.
Cardizem LA was given a pregnancy Category C rating because of potential problems in animal studies. When given to pregnant rabbits, mice, and rats, the drug caused increased miscarriages and birth defects (especially skeletal problems).
However, it is important to note that animals do not always respond to medicines the same way that humans do. Therefore, a pregnancy Category C medicine may be given to a pregnant woman if her healthcare provider believes that the benefits to the woman outweigh any possible risks to the unborn child.

Cardizem LA and Pregnancy: Final Thoughts

If you are pregnant or are thinking of becoming pregnant while taking Cardizem LA, let your healthcare provider know. He or she will consider both the benefits and risks of taking the drug when pregnant before making a recommendation in your particular situation.
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