Drugs That Can React With Clonidine
Clonidine Drug Interactions Explained
The following sections explain in detail the potentially negative interactions that can occur when clonidine is combined with any of the drugs listed above.
Anticoagulants or Antiplatelet Drugs
If you are taking an anticoagulant or antiplatelet drug, your healthcare provider may recommend against taking epidural clonidine, since "blood thinners" may increase the risk of dangerous side effects of epidurals. This is probably most significant for anticoagulants (warfarin, heparin, or heparin-like drugs) and less significant for antiplatelet drugs.
Combining clonidine with a beta blocker can increase the risk of dangerously low blood pressure (hypotension) or a dangerously slow heart rate (bradycardia). However, in many cases, such combinations can be safe and effective. Check with your healthcare provider before combining such medications.
If you take both clonidine and a beta blocker, stopping the clonidine (without stopping the beta blocker) could increase the risk of dangerously high blood pressure, strokes, and other serious problems. It is advised to stop taking the beta blocker several days before you gradually reduce the dose of clonidine. Do not attempt this without the approval and supervision of your healthcare provider.
Certain Calcium Channel Blockers
Combining clonidine with certain calcium channel blockers may cause dangerously low blood pressure and a slow heart rate (bradycardia). You may need to be monitored very closely if you take these medications together.
Combining clonidine with digoxin may cause a dangerously slow heart rate (bradycardia). You may need to be monitored very closely if you take these medications together.