Drug Interactions With Clonidine

Many medications can cause clonidine drug interactions, including beta blockers, digoxin, anticoagulant or antiplatelet drugs, and certain calcium channel blockers. These medications can increase your risk of developing dangerously low blood pressure, dangerously slow heart rate, or other serious problems. In order to help prevent interactions, make sure to tell your healthcare provider about all other medications you are taking before starting treatment.

An Overview of Drug Interactions With Clonidine

 Clonidine hydrochloride (Catapres®, Catapres-TTS®, Duraclon®) can potentially interact with several other medications. Some of these medicines that may lead to interactions with clonidine include:
 
  • Medications that "thin" the blood (anticoagulant and antiplatelet drugs), such as:

 

    • Aspirin (Bayer® and others)
    • Cilostazol (Pletal®)
    • Clopidogrel (Plavix®)
    • Dipyridamole (Persantine®)
    • Eptifibatide (Integrilin®)
    • Heparin or heparin-like products, including dalteparin (Fragmin®), enoxaparin (Lovenox®), or tinzaparin (Innohep®)
    • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:

 

 

 

 

 

 

 

  • Digoxin (Digitek®, Lanoxin®)
     
  • Other medications or substances that cause drowsiness, including, but not limited to:

 

 


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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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