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Diuril Warnings and Precautions

There is a lot of important information to be aware of before starting Diuril. Warnings and precautions include watching for certain drug interactions, reporting any signs of low blood pressure to your healthcare provider, and understanding that the drug may not be safe to use during pregnancy. Certain people should not take Diuril, including those who are allergic to any components of the medicine, aren't producing any urine, or are allergic to sulfonamides.

Diuril: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Diuril® (chlorothiazide) if you have:
  • Liver disease, including cirrhosis
  • Asthma
  • Kidney disease or kidney failure
  • Diabetes
  • Systemic lupus erythematosus (lupus or SLE)
  • Gout
  • Fluid or electrolyte problems, especially problems with high calcium levels (hypercalcemia)
  • Any allergies, including allergies to sulfa drugs, foods, dyes, or preservatives.
Also, let your healthcare provider know if you:
  • Are pregnant or trying to become pregnant
  • Are breastfeeding.
Tell your healthcare provider about all other medicines you are currently taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Some Precautions and Warnings With Diuril

Some Diuril warnings and precautions to be aware of include:
  • Diuril should not be started in people with liver problems because changes in fluid or electrolytes can be dangerous in people with liver disease.
  • If kidney problems seem to be getting worse (especially for those with very severe kidney disease), Diuril should be stopped, since the drug can sometimes worsen kidney problems.
  • You may be more likely to be allergic to Diuril if you have asthma. Be sure to talk to your healthcare provider before taking Diuril if you have asthma.
  • There are a number of medicines that Diuril can interact with (see Diuril Drug Interactions).
  • Diuril may cause extreme low blood pressure in some people. Extreme low blood pressure is more likely to occur when the medicine is first started or the dosage is changed. It is also more likely to happen in people who are on dialysis, have congestive heart failure, have diarrhea or vomiting, or sweat a lot. This is why it is important to drink fluids regularly while taking Diuril. If you have any possible symptoms of low blood pressure, such as dizziness, lightheadedness, or fainting, contact your healthcare provider. If you have fainted, stop taking Diuril until you have talked to your healthcare provider.
Also, make sure not to drive, operate any heavy machinery, or perform any other tasks that require alertness until you know how Diuril affects you.
  • Diuril can increase blood sugar levels, which is important for people with diabetes. Your healthcare provider may need to monitor your blood sugar more closely while you are starting or stopping Diuril.
  • Diuril may affect electrolytes in the blood (including sodium, calcium, potassium, magnesium, and chloride). Therefore, your healthcare provider will regularly check these levels. If you notice any symptoms of a possible electrolyte imbalance, contact your healthcare provider. These symptoms may include:
o Dry mouth
o Thirst
o Weakness
o Lethargy
o Drowsiness
o Restlessness
o Muscle pain or muscle cramps
o Low blood pressure (hypotension)
o Decreased urination
o Rapid heart rate (tachycardia) or irregular heart rhythm (arrhythmia)
o Nausea or vomiting.
  • Diuril is also known to worsen gout.
  • Diuril has been reported to worsen systemic lupus erythematosus or, in some cases, to even to cause the condition.
  • Diuril can cause high cholesterol and high triglycerides.
  • Diuril is considered a pregnancy Category C medication. This means that it may not be safe to use during pregnancy. Talk to your healthcare provider about the risks and benefits of using Diuril during pregnancy (see Chlorothiazide and Pregnancy for more information).
  • Diuril passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, be sure to talk with your healthcare provider about using Diuril (see Chlorothiazide and Breastfeeding for more information).
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Diuril Medication

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