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Important Safety Concerns With Fosinopril-Hydrochlorothiazide

Some Fosinopril-Hydrochlorothiazide Warnings and Precautions

Patients taking this drug should keep the following precautions and warnings in mind:
  • Fosinopril-hydrochlorothiazide is more likely than other drugs to cause allergic reactions. For example, there have been reports of severe allergic reactions occurring in people taking fosinopril-hydrochlorothiazide during dialysis. There have also been reports of severe reactions in people getting bee or wasp venom to protect against stings. Finally, people with a history of asthma or allergies are more likely to have an allergic reaction to fosinopril-hydrochlorothiazide.
Make sure to discuss these risks with your healthcare provider. Also, seek emergency medical attention immediately if you notice things such as hives, an unexplained rash, difficulty breathing, or swelling of the face or throat.
  • Medicines (like fosinopril-hydrochlorothiazide) that contain an ACE inhibitor may cause swelling (angioedema) of the head and neck, including the tongue, lips, eyes, or throat. This occurs more frequently in African Americans. Seek emergency medical care immediately if you notice swelling in the head or neck area, or if you have wheezing or difficulty breathing or swallowing.
  • In addition to head and neck angioedema, medicines like fosinopril-hydrochlorothiazide have been known to cause swelling in the intestines. This is known as intestinal angioedema. Symptoms may include stomach pain with or without vomiting. Seek medical attention immediately if you develop any of these symptoms.
  • Fosinopril-hydrochlorothiazide may cause extremely low blood pressure in some people. Extremely low blood pressure is more likely to happen when the medicine is first started or the dosage is changed. It is also more likely to happen in people who are taking a diuretic, who are on dialysis, who have congestive heart failure, who have diarrhea or vomiting, or who have excessive sweating. This is why it is important to drink fluids regularly while taking fosinopril-hydrochlorothiazide. If you have any possible symptoms of low blood pressure, such as dizziness, lightheadedness, or fainting, contact your healthcare provider. If you have fainted, stop taking fosinopril-hydrochlorothiazide until you have talked to your healthcare provider.
Also, make sure not to drive, operate any heavy machinery, or perform any other tasks that require alertness before you know how fosinopril-hydrochlorothiazide affects you.
  • People on fosinopril-hydrochlorothiazide can be at increased risk of infection. Talk to your healthcare provider if you develop any symptoms (such as a sore throat or fever) that might indicate an infection.
  • Fosinopril-hydrochlorothiazide is a pregnancy Category C medicine for the first trimester and a pregnancy Category D medicine for the second and third trimesters, meaning that fosinopril-hydrochlorothiazide poses health risks to your unborn child. Let your healthcare provider know if you are pregnant or thinking of becoming pregnant. If you become pregnant while taking fosinopril-hydrochlorothiazide, contact your healthcare provider immediately (see Monopril-HCT and Pregnancy for more information).
  • Medicines (such as fosinopril-hydrochlorothiazide) that contain an ACE inhibitor are known to cause a cough. If a cough becomes bothersome, talk to your healthcare provider about other treatment options for your condition (see Fosinopril Cough).
  • While taking fosinopril-hydrochlorothiazide, do not use potassium supplements or salt substitutes with potassium unless you have discussed this with your doctor. This is because in some people taking fosinopril-hydrochlorothiazide, potassium in the blood can increase or decrease to dangerous levels.
  • Medicines like fosinopril-hydrochlorothiazide have been known to cause a decrease in kidney function, especially in certain groups (such as those with severe congestive heart failure). Let your healthcare provider know if you have symptoms such as a decrease in urine output, drowsiness, headache, or back pain. Your healthcare provider will also regularly check your kidney function with a blood test.
  • In clinical studies, medicines that contain an ACE inhibitor, including fosinopril-hydrochlorothiazide, have rarely been known to cause liver failure. Contact your healthcare provider immediately if you notice things such as nausea, tiredness, lethargy, itchy or yellowing skin, abdominal pain, or flu-like symptoms.
  • If you have moderate to severe liver disease (such as cirrhosis), your body may metabolize the fosinopril-hydrochlorothiazide differently than intended. Therefore, your healthcare provider may start you on a lower dose of fosinopril-hydrochlorothiazide and will monitor your situation more closely, or may recommend another blood pressure medicine.
  • Fosinopril-hydrochlorothiazide may affect electrolytes in the blood (including sodium, potassium, magnesium, and chloride). Therefore, your healthcare provider will regularly check these levels. If you notice any symptoms of a possible electrolyte imbalance, contact your healthcare provider. These symptoms may include a dry mouth, increased thirst, weakness, tiredness, restlessness, seizures, confusion, muscle pain or cramps, decrease in urine output, weak or irregular heartbeat, nausea, or vomiting.
  • Because of the hydrochlorothiazide, fosinopril-hydrochlorothiazide is more likely to worsen systemic lupus erythematosus or, in some cases, even cause the condition.
  • Because of the hydrochlorothiazide, fosinopril-hydrochlorothiazide is also known to worsen gout.
  • Fosinopril-hydrochlorothiazide may cause high blood sugar (hyperglycemia) in diabetics or, in some cases, even cause diabetes in people without a history of the condition.
  • Fosinopril-hydrochlorothiazide may increase levels of cholesterol and triglycerides in the blood.
  • If you are nursing, certain parts of fosinopril-hydrochlorothiazide can pass through your breast milk. Therefore, if you are nursing, talk with your healthcare provider about whether you should stop taking fosinopril-hydrochlorothiazide or stop breastfeeding.
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