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Drugs That Interfere With Furosemide

Furosemide Interactions Explained

The following sections explain in detail the potentially dangerous interactions that can occur when furosemide is combined with any of the drugs listed above.
 
Aminoglycoside Antibiotics
Furosemide should not be combined with aminoglycoside antibiotics unless absolutely necessary. Taking these two medications together can increase the chance of permanent hearing loss.
 
Other Blood Pressure Medicine
When taking furosemide with another high blood pressure medication, your blood pressure may decrease too much. In addition, combining furosemide with certain types of blood pressure medications may increase the risk of kidney problems. In order to decrease the chances of these furosemide interactions, your healthcare provider may monitor you more closely and/or change the dose of either medicine.
 
Chloral Hydrate
There have been reports of flushing, sweating attacks, restlessness, nausea, increased blood pressure, and rapid heart rate when intravenous furosemide was given to people who had taken chloral hydrate within the past 24 hours. In general, this combination is not recommended.
  
Corticosteroids
Taking furosemide with corticosteroids may increase your risk of low potassium levels (hypokalemia). Your healthcare provider should check your potassium levels and may need to take steps to correct your potassium levels.
 
Cyclosporine
Combining furosemide with cyclosporine may increase the risk of gout, since this combination can lead to high levels of uric acid.
  
Digoxin (Digitek, Lanoxin)
Furosemide should be used carefully in people taking digoxin. Furosemide can cause low potassium levels (hypokalemia), which can be especially dangerous for people taking digoxin.
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