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More Furosemide Interactions

Ethacrynic Acid (Edecrin)
Furosemide should not be combined with ethacrynic acid due to the risk of hearing loss.
 
Laxatives
Prolonged use of laxatives may increase the risk of low blood potassium levels (hypokalemia) in people taking furosemide.
 
Licorice
Combining furosemide with large amounts of licorice may increase the risk of low potassium levels (hypokalemia). However, many "licorice" products contain little or no real licorice. For instance, red licorice does not contain any real licorice, and some black licorice products contain anise flavoring instead of licorice.
  
Lithium (Eskalith, Lithobid)
Taking furosemide with lithium may increase the level of lithium in your blood, increasing your chance of side effects. In general, it is usually not recommended to combine lithium with diuretics, including furosemide. Your healthcare provider may need to monitor your lithium level more closely and/or change your lithium dose.
 
Methotrexate
Combining methotrexate with furosemide may increase the toxicity of both medications while decreasing the effectiveness of furosemide. Check with your healthcare provider before taking these medications together.
  
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Taking furosemide with NSAIDs can make furosemide less effective and may increase your risk of side effects. Your healthcare provider may need to increase your dose of furosemide or may suggest an alternative to NSAIDs.
 
Phenytoin
Phenytoin may make Lasix less effective. Check with your healthcare provider before taking these medications together.
  
Salicylates
Taking furosemide with a salicylate can increase the level of the salicylate in your blood, increasing your risk of side effects. Talk with your healthcare provider before combining furosemide with salicylates.
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