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Drugs That Interfere With HCTZ

More Detail on HCTZ Interactions

 
Insulin
Taking insulin with HCTZ may cause high blood sugar (hyperglycemia). For your particular situation, your healthcare provider may monitor you more closely and/or adjust your dose of insulin as needed.
 
Oral Diabetes Medication
Taking an oral diabetes medication with HCTZ may increase blood sugar levels. For your particular situation, your healthcare provider may monitor you more closely and/or adjust your dose of diabetes medications as needed.
 
Other Blood Pressure Medicine
When taking HCTZ with another high blood pressure medication, your blood pressure may decrease too much. In order to decrease the chances of this HCTZ interaction, your healthcare provider may monitor you more closely and/or change the dose of either medicine.
 
Alcohol
When taking HCTZ with alcohol, your blood pressure may decrease too much. For your particular situation, make sure to talk with your healthcare provider about drinking alcohol while taking HCTZ.
 
Barbiturates
When taking HCTZ with a barbiturate, your blood pressure may decrease too much. In order to decrease the chances of this HCTZ interaction, your healthcare provider may change the dose of either medicine, start you on a lower dose of HCTZ, and/or monitor you more closely.
 
Narcotics
When taking HCTZ with a narcotic, your blood pressure may decrease too much. In order to decrease the chances of this interaction, your healthcare provider may change the dose of either medicine, start you on a lower dose of HCTZ, and/or monitor you more closely.
 
Cholestyramine (Prevalite, Questran, Questran Light, LoCholest)
Cholestyramine can bind to HCTZ in the digestive tract and decrease its absorption into the body. To avoid this drug interaction, HCTZ should be taken at least one hour before or four to six hours after cholestyramine has been given.
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