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More Info on Drug Interactions With HCTZ

Colestipol (Colestid)
Colestipol can bind to HCTZ in the digestive tract and decrease its absorption into the body. To avoid this drug interaction, HCTZ should be taken at least one hour before or four to six hours after colestipol has been given.
 
Corticosteroids
Taking corticosteroids with HCTZ may cause an electrolyte imbalance, especially with the levels of potassium in the blood. If you are taking a corticosteroid with HCTZ, your healthcare provider may monitor you more closely and/or adjust your dose of medicine as needed.
 
Norepinephrine
Norepinephrine is a medicine that is used to treat very low blood pressure. HCTZ may affect norepinephrine's ability to raise blood pressure.
 
Corticotropin
Taking corticotropin with HCTZ may cause an electrolyte imbalance, especially with the levels of potassium in the blood. If you are taking corticotropin with HCTZ, your healthcare provider may monitor you more closely and/or adjust your dosage as needed.
 
Muscle Relaxants
If you are taking HCTZ with a muscle relaxant, your body may metabolize the drugs differently than intended and increase the muscle relaxant levels in the blood. In order to decrease the chances of developing this drug interaction, your healthcare provider may monitor you more closely and/or change the muscle relaxant dose.
 
Lithium (Eskalith, Lithobid)
Taking HCTZ with lithium may increase the level of lithium in your blood, increasing your chance of side effects. In general, lithium is usually not recommended if you are taking diuretics, such as HCTZ. Your healthcare provider may need to monitor your lithium level more closely and/or change your lithium dose.
 
NSAIDs
Taking HCTZ with NSAIDs can make HCTZ less effective. Your healthcare provider may need to increase your dose of HCTZ or suggest alternatives to the medication.
 
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HCTZ Diuretic

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