Precautions and Warnings With Indapamide

There are many precautions and warnings with indapamide to be aware of before starting the medication. For example, you should let your healthcare provider know if you have gout, diabetes, or electrolyte problems prior to beginning treatment. You should not take indapamide if you are allergic to any components of the drug, are allergic to sulfonamides, or are not producing any urine.

• Kidney disease or kidney failure
• Diabetes
• Gout
• Fluid or electrolyte problems
• Any allergies, including allergies to sulfa drugs, foods, dyes, or preservatives.
   

• Are pregnant or trying to become pregnant (see Indapamide and Pregnancy)
• Are breastfeeding (see Indapamide and Breastfeeding).
   

• Indapamide may affect electrolytes in the blood (including sodium and potassium). Therefore, your healthcare provider will regularly check these levels. If you notice any symptoms of a possible electrolyte imbalance, contact your healthcare provider. These symptoms may include:

o Dry mouth

o Thirst

o Weakness

o Lethargy

o Drowsiness

o Restlessness

o Muscle pain or muscle cramps

o Low blood pressure (hypotension)

o Decreased urination

o Rapid heart rate (tachycardia) or irregular heart rhythm (arrhythmia)

o Nausea or vomiting.

• If kidney problems seem to be getting worse (especially for those with very severe kidney disease), indapamide should be stopped, because the drug can sometimes make kidney problems worse.
   
• There are a number of medicines that indapamide can interact with (see Drug Interactions With Indapamide).
   
• Indapamide is also known to worsen gout.
   
• Indapamide may cause high blood sugar (hyperglycemia) in people with diabetes or (in some cases) even cause diabetes in people without a history of the condition.
   
• Indapamide is considered a pregnancy Category B medication. This means that it is probably safe to use during pregnancy, although the full risks are not known. Talk to your healthcare provider about the risks and benefits of using indapamide during pregnancy (see Indapamide and Pregnancy for more information).
   
• It is not known if indapamide passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, be sure to talk with your healthcare provider about using indapamide (see Indapamide and Breastfeeding for more information).