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Specific Irbesartan/HCTZ Interactions

Taking irbesartan/HCTZ within 24 hours of receiving amifostine could lower your blood pressure to unsafe levels. Talk to your healthcare provider about this possible interaction if you are receiving amifostine treatment.
Taking a barbiturate with irbesartan/HCTZ may lower your blood pressure to unsafe levels, especially when moving from a seated to a standing position. Talk to your healthcare provider about this potential interaction before taking these medications together. Also let your healthcare provider know if you become dizzy, lightheaded, or faint while taking these medications together.
Bile Acid Sequestrant Cholesterol Medications
Bile acid sequestrant medications can bind to irbesartan/HCTZ in the gastrointestinal tract and decrease the amount of the medication absorbed into the body. Irbesartan/HCTZ should be taken at least one hour before or four to six hours after a bile acid sequestrant to help minimize this interaction.
Calcium Supplements or Calcium-Containing Antacids
Taking irbesartan/HCTZ with calcium products may increase blood calcium levels (hypercalcemia). Talk to your healthcare provider before using calcium supplements, or antacids that contain calcium, if you take irbesartan/HCTZ.
Taking irbesartan/HCTZ with calcitriol may cause an elevated blood calcium level (hypercalcemia). Your healthcare provider may choose to monitor your blood calcium levels if you take these medications together.
Taking corticosteroids with irbesartan/HCTZ could cause low blood potassium levels (hypokalemia), or other electrolyte problems. If you take these medications together, your healthcare provider may monitor your blood electrolyte levels more closely.
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