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Can I Take Irbesartan/HCTZ With Other Drugs?

Diabetes Medications
Irbesartan/HCTZ may decrease the effectiveness of medications used to treat diabetes. If you are taking a medication for diabetes, your healthcare provider may monitor your blood sugar levels more closely when you first start taking irbesartan/HCTZ, or when your irbesartan/HCTZ dosage is increased.
 
Dofetilide
Taking dofetilide with hydrochlorothiazide (one of the medications in irbesartan/HCTZ) may cause abnormal heart rhythms, including a potentially dangerous condition called QT prolongation. The manufacturer of dofetilide recommends that these medications not be taken together.
 
Eplerenone
If you take irbesartan/HCTZ with eplerenone, the level of potassium in your blood may become too high. Your healthcare provider may choose to monitor your blood potassium level if you take these medications together.
 
Lithium
Irbesartan/HCTZ may increase blood lithium levels, potentially causing lithium toxicity. Your healthcare provider may choose to monitor your blood lithium levels when you first start irbesartan/HCTZ. You may need a lower lithium dosage. Contact your healthcare provider right away if you have symptoms of lithium toxicity, such as confusion, tremors, or coordination problems, while taking these medications together.
 
Narcotic Pain Relievers
When taking irbesartan/HCTZ with a narcotic pain reliever, your blood pressure may drop too much, especially when moving from a seated to standing position. Talk to your healthcare provider about this potential interaction, and watch for signs of low blood pressure if you take these medications together. Symptoms of low blood pressure may include dizziness, lightheadedness, or fainting.
 
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Irbesartan/HCTZ can interact with NSAIDs in several ways. The combination could cause your blood pressure to increase or may cause swelling (edema), especially if you have congestive heart failure (CHF). If you are elderly, have kidney disease or kidney failure, or are taking a diuretic ("water pill") or are dehydrated, taking NSAIDs and irbesartan/HCTZ together may cause kidney failure. Talk to your healthcare provider about this potential drug interaction before taking these medications together.
  
Other Blood Pressure Medications
Taking irbesartan/HCTZ with another high blood pressure medication may lower your blood pressure to unsafe levels. You may need close monitoring of your blood pressure if you take multiple blood pressure medications. Your healthcare provider may recommend you take irbesartan/HCTZ with another blood pressure medication if irbesartan/HCTZ alone does not control your blood pressure.
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