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Should I Care About Irbesartan/HCTZ Interactions?

Combining irbesartan/HCTZ with trimethoprim, or a medication containing trimethoprim, could increase your risk for high blood potassium (hyperkalemia). Your healthcare provider may want to monitor your blood potassium levels if you take these medications together.
Yohimbe may decrease the effectiveness of irbesartan/HCTZ, meaning that it may not work as well to lower your blood pressure. If you take irbesartan/HCTZ, do not take yohimbe without first talking to your healthcare provider.

Final Thoughts

It is possible that not all drug interactions with irbesartan/HCTZ were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific interactions that may apply to you.
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