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Drug Interactions With Irbesartan/HCTZ

Some medications, such as barbiturates, corticosteroids, and narcotic pain relievers, can cause negative drug interactions when taken with irbesartan/HCTZ. These reactions can alter the amount of the medications in your blood, possibly causing side effects or lowering your blood pressure to unsafe levels.

An Overview of Irbesartan/HCTZ Interactions

Irbesartan/HCTZ (Avalide®) may potentially react with many other medications. Some of the drugs that may lead to irbesartan/HCTZ interactions include but are not limited to:
 
 
  • Allopurinol (Zyloprim®)
  • Amifostine (Ethyol®)
  • Barbiturates, such as:
    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)
 
 
  • Calcium supplements or calcium-containing antacids
  • Calcitriol (Rocaltrol®, Calcijex®)
  • Corticosteroids, such as:
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Orapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)
 
 
 
  • Other blood pressure medications
  • Pentoxifylline (Trental®)
  • Potassium-containing products, such as:
    • Potassium chloride (K-Dur®, Klor-Con®, Micro-K®)
    • Potassium citrate (Urocit-K®, Polycitra-K®)
    • Potassium gluconate
    • Potassium phosphate (Neutra-Phos-K®, K-Phos®)
    • Salt substitutes (used to flavor food)
 
 
  • Pressors, such as:
    • Dopamine (Intropin®)
    • Dobutamine (Dobutrex®)
    • Epinephrine (Adrenalin®, EpiPen®)
    • Norepinephrine (Levophed®)
 
  
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Irbesartan/Hydrochlorothiazide Drug Information

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