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Understanding How Irbesartan/HCTZ Works and Specific Indications

How Does This Medication Work?

The two drugs in irbesartan/HCTZ work in different ways to lower blood pressure. Irbesartan belongs to a class of medications called angiotensin II receptor blockers (or commonly "ARBs").
 
Angiotensin II narrows (constricts) blood vessels, making it more difficult for the heart to pump blood through them. This causes blood pressure to increase. Irbesartan blocks angiotensin II receptors, preventing angiotensin II from narrowing the blood vessels. The blood vessels stay relaxed, and blood pressure lowers.
 
Hydrochlorothiazide (HCTZ) is a diuretic or "water pill." It works by increasing the amount of salt and water the kidneys remove from the blood. This extra salt and water is then passed out through the urine. The removal of salt and water decreases blood volume, resulting in lower blood pressure.
 

Is Irbesartan/HCTZ Safe for Use in Children?

This medication is not approved for use in children (usually defined as people younger than 18 years of age). It has not been adequately studied in this age group.
 

Is Irbesartan/HCTZ Safe for Use in Older Adults?

In clinical studies of irbesartan/HCTZ, older adults did not respond any differently to the medication than younger age groups. However, there were very few older adults in these trials. Some older adults may be more sensitive to the effects of the medication. Therefore, some older adults may need to start on a lower irbesartan/HCTZ dosage.
 

Is It Used for Off-Label Reasons?

On occasion, your healthcare provider may recommend this medicine for something other than the treatment of high blood pressure. This is called an "off-label" use. At this time, there are no universally accepted off-label uses for irbesartan/HCTZ.
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Irbesartan/Hydrochlorothiazide Drug Information

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