Carbamazepine
Isoptin SR can increase the level of
carbamazepine in your blood, possibly increasing your risk of side effects. Your healthcare provider may need to decrease your
carbamazepine dosage if you are taking both of these drugs.
Chemotherapy Medications
Isoptin SR can interact with various chemotherapy medications, causing a variety of effects. Always make sure to tell all of your healthcare providers about any medications you are taking.
Cimetidine
Cimetidine may increase the level of Isoptin SR in your blood, potentially increasing your risk of
Isoptin SR side effects (although drug interaction studies have shown mixed results). Your healthcare provider may need to adjust your Isoptin SR dose or may suggest an alternative to cimetidine.
Cyclosporine
Isoptin SR may increase the level of cyclosporine in your blood, possibly increasing your risk of side effects. Your healthcare provider should closely monitor your cyclosporine levels and may need to adjust your dosage.
Digoxin
Isoptin SR may increase the level of digoxin in your blood, although studies have shown conflicting results. Because changes in digoxin levels can be dangerous, your healthcare provider should closely monitor the digoxin level in your blood and adjust the dosage as necessary. Your healthcare provider should also monitor your heart rate, as Isoptin SR and digoxin can both lower your heart rate.
Disopyramide
Because both disopyramide and Isoptin SR decrease the heart's ability to pump blood forcefully, disopyramide should not be taken within 48 hours before or 24 hours after taking Isoptin SR.
Flecainide
Combining Isoptin SR with flecainide may decrease the heart's ability to pump blood forcefully and may decrease the heart rate too much. Your healthcare provider should monitor you closely when combining these two medications.
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