Drug Interactions With Lisinopril-Hydrochlorothiazide

More Detail on Interactions With Lisinopril-Hydrochlorothiazide

Diuretics (Lasix, Demadex)
When taking lisinopril-hydrochlorothiazide with a diuretic, your blood pressure may decrease too much. This is more likely to occur when you first start taking lisinopril-hydrochlorothiazide. In order to decrease the chances of experiencing this interaction, your healthcare provider may change the dose of either medicine, start you on a lower dose of lisinopril-hydrochlorothiazide, and/or monitor you more closely.
 
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
If you have kidney disease or kidney failure, taking both NSAIDs and lisinopril-hydrochlorothiazide may add to the damage that your kidneys are already suffering. Also, NSAIDs may decrease the blood pressure-lowering effects of lisinopril-hydrochlorothiazide. Talk to your healthcare provider about using NSAIDs and lisinopril-hydrochlorothiazide together in your situation.
 
Potassium Supplements or Salt Substitutes With Potassium
If you are taking lisinopril-hydrochlorothiazide with a potassium supplement or a salt substitute with potassium, the levels of potassium in your blood may become too high. This can cause serious problems. Ask your healthcare provider about using potassium and lisinopril-hydrochlorothiazide together in your situation.
 
Potassium-Sparing Diuretics (Midamor, Dyrenium, Aldactone)
If you are taking both lisinopril-hydrochlorothiazide and a potassium-sparing diuretic, your body may metabolize them differently than intended, increase the levels of potassium in your blood, or both. Your healthcare provider may choose to monitor your progress closely.
 
Lithium (Eskalith, Lithane, Lithonate, Lithotabs)
If you are taking both lisinopril-hydrochlorothiazide and lithium, your body may metabolize the drugs differently than intended and increase the lithium levels in the blood. Your healthcare provider may choose to monitor your serum lithium levels more frequently.
(Drug Interactions With Lisinopril-Hydrochlorothiazide Continued: Page 3)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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