Drug Interactions With Lisinopril-Hydrochlorothiazide

Narcotics
When taking lisinopril-hydrochlorothiazide with a narcotic, your blood pressure may decrease too much. To decrease your chances of having such an interaction, your healthcare provider may change the dose of either medicine, start you on a lower dose of lisinopril-hydrochlorothiazide, and monitor you more closely.
 
Cholestyramine (Prevalite, Questran, Questran Light, LoCholest)
Cholestyramine can bind to lisinopril-hydrochlorothiazide in the digestive tract and decrease its absorption into the body. To avoid this drug interaction, take lisinopril-hydrochlorothiazide at least one hour before or four to six hours after taking cholestyramine.
 
Colestipol (Colestid)
Colestipol can bind to lisinopril-hydrochlorothiazide in the digestive tract and decrease its absorption into the body. Therefore, take lisinopril-hydrochlorothiazide at least one hour before or four to six hours after taking colestipol to avoid this drug interaction.
 
Corticosteroids (Hexadrol, Cortef, Decadron)
Taking corticosteroids with lisinopril-hydrochlorothiazide may cause an electrolyte imbalance, especially with the levels of potassium in the blood. If you are taking a corticosteroid with lisinopril-hydrochlorothiazide, your healthcare provider may monitor you more closely and adjust your dose of medicine as needed.
 
Norepinephrine
Norepinephrine is a medicine that is used to treat very low blood pressure. Lisinopril-hydrochlorothiazide may affect the ability for norepinephrine to raise blood pressure.
 
Corticotropin (Acthar)
Taking corticotropin with lisinopril-hydrochlorothiazide may cause an electrolyte imbalance, especially with the levels of potassium in the blood. If you are taking corticotropin with lisinopril-hydrochlorothiazide, your healthcare provider may monitor you more closely and adjust your dose as needed.
(Drug Interactions With Lisinopril-Hydrochlorothiazide Continued: Page 5)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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